International Journal of Farmacia International Journal of Farmacia

ISSN: 2455-8109

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  1. Formulation and Evaluation of Pantoprazole Sodium Enteric Coated TabletsDownload Article

    Rahmath Unnisa Begum, Dr. Syed Abdul Azeez Basha

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    Pantoprazole is a proton pump inhibitor belongs to group of benzimidazole which has been widely used in the treatment of gastric, duodenal ulcer and also in gastro-esophageal reflux disease (GERD), Zollinger Ellison syndrome. It suppresses the acid production by inhibiting the H+ K+ ATP’ase. Pantoprazole is an acid labile drug, which can be degraded in the stomach. In aqueous media more acidic than pH 4 it suffers a practically complete decomposition within a period shorter than 10 minutes. Pantoprazole which have an irritant effect on the stomach, can be coated with a substance that will only dissolve in the small intestine. For such types of drugs, enteric coating added to the formulation tends to avoid the stomach's acidic exposure, delivering them instead to a basic pH environment (intestines pH 5.5 and above) where they do not degrade, and give their desired action. The prepared tablets were evaluated for hardness, thickness, weight variation, friability & drug content uniformity and the results were found to comply with official standards. The prepared tablets were coated using an enteric coating polymers such as Eudragit L100, PVAP, Eudragit RS100 by the spray coating method. The in vitro release was studied using pH 1.2 acidic buffer and pH 6.8 phosphate buffer and the study revealed that the prepared tablets were able to release the drug in the intestine, from the Prepared all batch’s EC8 was found best, The optimized formulation EC8 shows the average thickness of 2.2 mm, average hardness of 3.52 (kg/cm2), average weight variation of 213 mg, friability of 0.46%, drug content 101.2 %, disintegration time 1min 10sec, cumulative % drug release 100.16% within 2hrs 45mins and acid resistance time of about 2hrs. Stability studies indicated that the developed tablets were stable and retained their pharmaceutical properties at room temperature and 40 °C / 75% RH for a period of 3 month.

  2. RP-HPLC method development & validation for estimation of Flecainide acetate in bulk and tablet dosage formDownload Article

    Md.Musthafa, Ravi Kumar Vejendla, J.Srawanthi, Arshiya Jabeen, K.Sindhu

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    A novel stability indicating liquid chromatographic assay method was developed and validated as per ICH guide lines for the quantitative estimation of Flecainide in tablet formulation. An isocratic reverse phase LC-method was developed using C18 ODS 250cm x 4mm x 5µm particle size column and a mobile phase comprising of a mixture of buffer: acetonitrile (40:60), pH adjusted to 3.0 with Ammonium di-hydrogen phosphate. The detector set at 299nm with flow rate of 1.0ml min-1. The method is linear between 5µg ml-1 to 25µg ml-1 and the limit of detection (LOD) is 0.5 µg ml-1. The Accuracy of the method was found to be in the range of 99.70% to 100.26%. The mean Inter and Intraday assay Relative Standard deviation (% RSD) were less than 0.69%. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Flecainide in tablet formulations and can be used for commercial purposes.

  3. Formulation and in vitro evaluation of Vincristine microemulsion by using nigella sativa oilDownload Article

    Tahseen Maryam, Balaji

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    Vincristine is an anti-metabolite having an anti-cancer its having low aqueous solubility hence formulated microemulsion will increase its solubility and thus improves the oral bioavailability selection of nigella sativa oil is due to its anti-cancer property and the solubility of drug in oil (70mg/ml).micro emulsion was prepared by phase titration method using nigella sativa oil, tween 80, tween 20, water..8blank formulations were formulated based on various physical parameters clarity, stability, density, viscosity, ph, and electrical conductivity,3formulations were narrowed down, drug loaded in previously  selected blank microemulsion formulation the particle size study was carried out by zeta analysis and the results proved that the formulations were micron sized. Ftir studies proved that there was not much interaction between the drugs in the formulation. In-vitro dissolution studies were performed for all the 17 formulations individually for both the drugs was found. The optimized formulation was sustained release this formulation was subjected to ex-vivo diffusion study and the permeation through the membrane was found.

  4. Formulation and evaluation of Furosemide oral dispersible tabletsDownload Article

    Tarannum, Dr. Shahid Mohammed

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    The oral disintegrating tablets of furosemide with sufficient mechanical strength, acceptable taste and smaller disintegration time were achieved employing suitable superdisintegrants and other excipients at optimum concentration. FTIR studies revealed that there was no shift in peaks, indicating there is no interaction between furosemide and other ingredients used. Among three superdisintegrants used sodium starch glycolate showed better performance in disintegration time when compared to crospovidone and cross caramellose sodium used alone. In the invitro dissolution study comparison among all formulations, OF5 showed best results. So the formulation of OF5 was found to be best among all other formulations, because it has exhibited good taste and faster disintegration time when compared to all other formulations.

  5. Preparation and evaluation of sustained release matrix tablets of Repaglinide (USP) using natural polymersDownload Article

    Mahmooda, Dr. Syed abdul azeez basha

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    The objective of the present work is to develop and characterizes oral sustain release matrix tablets of Repaglinide. Repaglinide is practically insoluble in water so it is suitable to develop sustained release matrix tablet using hydrophilic polymers. Repaglinide is anti-diabetic drug used extensively in the treatment of diabetes type II. The natural polymers like carrageenan, chitosan, gum karaya, Bhara gum were utilized in the formulation of matrix tablets containing Repaglinide by wet granulation technique and evaluated for its drug release characteristics. Granules were prepared and evaluated for its physical properties and shows satisfactory results. Formulation was optimized on the basis of acceptable tablet properties (hardness, friability, drug content and weight variations), in vitro drug release and stability studies. All the formulations showed compliance with Pharmacopeial standards. The in vitro release study of matrix tablets were carried out in phosphate buffer pH 6.8 for 12 hr. Among all the formulations, F2 with shows 100% better controlled release at the end of 12 hrs when compared to other formulations. The release data was fitted to various mathematical models such as, Higuchi, Korsmeyer-Peppas, First-order, and Zero order to evaluate the kinetics and mechanism of the drug release. The drug release of optimized formulations F2 follows zero order kinetics and the mechanism was found to be diffusion coupled with erosion (non-Fickian diffusion). The stability studies were carried out according to ICH guideline which indicates that the selected formulations were stable.