International Journal of Farmacia International Journal of Farmacia

ISSN: 2455-8109

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  1. Analytical method development and validation for the estimation of Nimesulide and Tizanidine using RP-HPLCDownload Article

    Kaifi Azmath, R. Vani

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    A simple and selective HPLC method is described for the determination of Tizanidine and Nimesulide in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 35 volumes of water and 65 volumes of Methanol with detection of 243nm. Linearity was observed in the range 20-100 µg/ml for Tizanidine (r2 =0.999) and 20-100 µg /ml for Nimesulide   (r2 =0.999) for the amount of drugs estimated by the proposed methods were in good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.

  2. Development, optimization and invitro characterization of Losartan potassium gastroretentive bioadhesive tabletsDownload Article

    Pamu Sandhya, Shireen Begum

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    Losartan bioadhesive tablets were prepared by direct compression method. The tablets were evaluated for pre compression and post compression parameters, swelling studies and in-vitro drug release. The formulation with desired drug release was tested for stability. The formulation F8 was selected as the best formulation, as the release of Losartan from the formulation was found to be zero order kinetics and Korsmeyer-Peppas model. The optimized formulation was found to have good mucoadhesive strength in sheep gastric mucosa and showed drug release up to 12 hours (99.8 %).Therefore, bimodal drug release pattern was successfully achieved through the formulation of bioadhesive tablets in this study. Formulating bioadhesive tablets of losartan increased the bioavailability to 99.8 % with the use of polymer carbopol.

  3. Formulation and evaluation of osmotic tablets of RanolazineDownload Article

    Saba Sultana, Pamu Sandhya, M. Sunitha

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    Ranolazine is a clinically effective antianginal agent that has been used as the sodium- dependent calcium ion influx inhibitor and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. Osmotic tablets of ranolazine were prepared by using polymers like HPMC K4M, lactose, povidone K-30, carbopol. The effect of the storage at high temperatures at 40°C, 50°C and 60°C for a period of 3 months on the chemical stability of the selected tablets and prediction of the shelf life was also assessed. Nine formulations were formulated. Pre-compression parameters such as Angle of repose, bulk density, Carr’s index, Haunser ratio were evaluated. The purpose of this work was to formulate a solid dosage form for Ranolazine using the principles of osmosis which will bring down its dosing frequency to once a day and at the same time produce a zero-order release system.