International Journal of Farmacia International Journal of Farmacia

ISSN: 2455-8109

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  1. Development and evaluation of gastroretentive tablets of SimvastatinDownload Article

    Sana Fatima, Pamu Sandhya

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    Simvastatin is a lipid lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. It is used to lower cholesterol and triglycerides (types of fats) in the blood. It is also used to lower the risk of stroke, heart attack and other heart complications in people with diabetes and coronary heart disease. Common side effects of simvastatin may include headache, constipation, nausea and stomach pain. The GFDDS of simvastatin were developed in the form tablets comprising of an effervescent agent. The GFDDS of simvastatin prepared from HPMC remained intact and the compactness of the tablets was not affected during the invitro dissolution test.

  2. Development and invitro evaluation of gastroretentive floating effervescent matrix tablets of EnalaprilDownload Article

    Syeda Ahmedi Aqsa, Pamu Sandhya

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    Enalapril is a potent ACE inhibitor which is rapidly metabolized in the liver.It is rapidly converted by ester hydrolysis to Enalaprilat on oral administration. It may be used to treat renovascular hypertension, symptomatic congestive heart failure and hyperglycaemia. It may be used alone or in combination with thiazide diuretic. However its absorption is erratic in diabetic patients due to impaired gastric motility so, to overcome this the present study gastric retentive controlled release dosage form of the drug was formulated with different polymers like HPMC K15M, sodium bicarbonate, magnesium stearate, MCC, talc in different ratios. In this direct compression method has been employed to prepare floating matrix tablets. The formulations F1-F12 were formulated and evaluated for various quality control parameters. All the formulations were passed the tests and the results were within limits. From the dissolution data it was evident that formulation F11 was found to be best formulation with maximum % drug release of 99.92 % in 12 hours.

  3. Formulation, invitro evaluation & stability studies of the bilayered tablets of glipizide and pioglitazoneDownload Article

    Romana Siddiqua

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    The objective of present investigation was to formulate and evaluate bilayered tablets containing Pioglitazone (I.R) & Glipizide (S.R).The Bilayered tablets prepared by direct compression method. The sustained release layer is prepared by wet granulation method using synthetic and natural polymers like HPMC K4M, Ethylcellulose, and Guargum & Xantham gum. The immediate release layer is prepared by direct compression method using superdisintegrants like Crosscamellose sodium; Crosspovidone & Sodium starch glycolate (SSG). The physicochemical evaluation results for the powdered blend of all trials pass the official limits in Bulk density, Tapped density, Compressibility index, Hausner ratio, and Angle of repose. The formulated tablets were evaluated for thickness, weight variation test, hardness test, friability test and drug content. The prepared tablets exhibited satisfactory physico-chemical characteristics. The formulation (F6) having immediate release layer of Pioglitazone showed 100.8%drug release within 60min & the formulation (F4) having sustained release layer of Glipizide showed 100.1% drug release within 12 hours. The drug release from the tablets was sufficiently sustained. The kinetic modeling of in vitro dissolution profiles revealed diffusion release mechanism. The stability studies revealed no significant changes in physical and chemical properties for the optimized formulation.

  4. Formulation and evaluation of controlled drug release naproxen pelletsDownload Article

    Dr.A.Yasodha, G. Anuhya Goud, Kommagoni Swathi, G. Venkataih, A.Sivakumar

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    The ultimate dosage forms for pellets can be capsule or they may be compressed into disintegrating tablets. Interest in this area has been increasing continuously, since it offers some important pharmacological as well as technological advantages. Extrusion -Spheronization may be defined as a process in which a wet mass is extruded through a specific sieve with fixed diameter and subsequently spheronized into spherical particle called as spheroids, pellets or beads depending upon materials and process used for Extrusion –Spheronization. Controlled release pellets have minimum volume in size, greater surface area and more surface activity. The area of the drug loaded pellets release rate was also more. And also there was no need of disintegration time for pellets in capsules.  Small volumes of pellets enter into the systemic circulation very fast.  Moreover there was no accumulation of drug in the body. Drug release rate was more when compared with that of other formulations. Naproxen controlled release pellets were filled into capsules. It showed good results in formulation of stable dosage. The dissolution profile was determined for all the formulations. Formulation F9 was considered as optimized formulation in terms of percentage cumulative drug release, coating build up, chanelling agent ratio etc.