International Journal of Farmacia International Journal of Farmacia

ISSN: 2455-8109

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  1. Tastease-m gummies ; a nutritional support for attention, mental focus and cognitive functioning along with immune enhancing colostrumDownload Article

    Govind Shukla, Neha S.Giri, Meghla R, C.J. Sampath Kumar

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    Gummy bears (German: Gummibär) are small, fruit gum candies, similar to a jelly baby . The candy is roughly 2 cm (0.8 in) long and shaped in the form of a bear. The gummy bear Tastease-M is a unique combination of nutrients & botanicals demonstrated to enhance immunity,attention,mentalfocus and cognitive function.it is formulated in a tasty gummy form for ease of administration due to the fact that any nutrient deficiency can impair brain function. Tastease-M contains DHA & colostrums for optimum Immunity. This review summarises the current available scientific literature regarding the effect of  TASTEASE-M Gummies, A Nutritional Support For Attention, Mental focus & cognitive functioning along with immune enhancing colostrum.

  2. Formulation and evaluation of nicotine buccal patchesDownload Article

    A.Vibhavari, Sravanthi Todasam

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    The work presented in this evaluates the use of buccal formulation for the enhancement of bioavailability of Nicotine. Buccal delivery of this drug bypasses the liver, thereby first-pass metabolism is avoided which resulted in the improvement of bioavailability. The feasibility of delivering Nicotine was investigated by conducting ex vivo permeation studies using fresh porcine buccal mucosal membrane. Quality control tests were carried out followed by in vitro release studies, moisture absorption studies, in vitro residence time and evaluation of mechanical properties. Finally, a suitable formulation was selected and permeation studies of patches were conducted ex vivo by using fresh porcine buccal mucosal membrane.

  3. Fabrication, Characterization and Evaluation of Curcumin-Bioenhancer NanosuspensionDownload Article

    Kathiresan Krishnasamy, Devi Thamizhanban

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    Curcumin, a hydrophobic polyphenol displays various pharmacological activities however, low aqueous solubility limits its clinical application. The primary aim of the study was to prepare Curcumin-piperine nanosuspension and to assess its anti-bacterial efficacy on Escherichia coli in comparison with ethanolic solution of curcumin. Curcumin-piperine nanosuspension was prepared by nanoprecipitation method, characterized for the average particle size, span, uniformity, surface area, and surface morphology and assessed for its anti-bacterial activity against gram-negative bacteria Escherichia coli using agar well diffusion method. Prepared Curcumin-piperine nanosuspension showed an average particle size of about 200 nm, span of about 1.25, uniformity of about 1.0 and surface area of about 65 m2/g. and nanoparticles were spherical in shape. Curcumin nanosuspension have shown significant (P<0.05) anti-bacterial activity against Escherichia coli at various concentrations in comparison with ethanolic solution of curcumin. We conclude that the size reduction of curcumin and piperine in nano range has increased the surface area resulting in increased aqueous solubility and reactability of curcumin and piperine, which in turn have increased the potency of curcumin-piperine nanosuspension.

  4. Validation of developed analytical method for bacampicillin floating tablets by reverse phase high performance liquid chromatographyDownload Article

    P.Sureshkumar, Gunasekaran.V, Jayabalan.G

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    Aim of the present investigation was to validate a new analytical, simple, sensitive, selective and precise High Performance Layer Chromatographic (HPLC) method for the estimation of Bacampicillin in tablet dosage form. Bacampicillin is chemically1-Ethoxycarbonyloxyethyl (2S, 5R)-6-[[(2R)-2-amino-2-phenylacetyl] amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylate. The mobile Phase comprised of Methanol: water (350:650) and set at a flow rate of 1.2ml/minute. Detection was carried out at 293nm using pre-packed Symmetry C18; 250x4.6mm, 5µm particle size column. The retention time of Bacampicillin was found to be 2.978. The assay was linear over concentration range of 12.5µg/ml to 75µg/ml (R=0.9998). The limit of detection and the limit of quantification were found to be 1.47µg/ml and 4.46µg/ml respectively. The amount of Bacampicillin was found to be 100.88±0.89 and the accuracy of Bacampicillin was found to be 99.60% to 101.60%. The statistical analysis of the data showed that the method is reproducible and selective for the estimation of Bacampicillin in tablet dosage form during routine analysis.