International Journal of Farmacia International Journal of Farmacia

ISSN: 2455-8109

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  1. Antisense oligonucleotide therapyDownload Article

    Karra Geetha, Pooja Kumari, Saidinesh, Y. Srikala

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    An antisense oligonucleotide (ASO) is a short strand of deoxyribo nucleotide analogue that hybridizes with the complementary mRNA in a sequence-specific manner via Watson–Crick base pairing. A new way to block protein function is to prevent the translation of messenger RNA (mRNA) into protein where treatment involves modulation of gene expression. These agents not only used in genetic disorder but also for non-genetic disorder. The current status and future directions of several antisense drugs that have potential clinical use in cancer are reviewed. In the present review, we discuss various theoretical approaches to rational design of ASO, chemical modifications of ASO, ASO delivery systems and ASO-related toxicology. Finally, we survey ASO drugs in various current clinical studies.

  2. Nanotechnology in cancer therapy-reviewDownload Article

    Karra Geetha, K. Manogna, Ch. Vamshi Krishna, A. Shashi Devi

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    Nanotechnology is rapidly developing subdivision of technology that affects on many fields. Medicine is also affected from nanotechnology; since, in cancer treatment nanotechnologically modified methods can be used. One of the developing usage fields of nanotechnology is cancer treatment. Nanotechnology is the study and use of structures between 1 nanometer and 100 nanometers in size. Nanotechnology has the potential to increase the selectivity and potency of chemical, physical, and biological approaches for eliciting cancer cell death while minimizing collateral toxicity to non malignant cells. Materials on the nanoscale are increasingly being targeted to cancer cells with great specificity through both active and passive targeting. Nanotechnology can assist to have better diagnosis with less harmful substances as optical nanoparticles and ICG molecules, to provide efficient drug delivery to tumor cells with liposomes and functionalized micelles. Finally, nanotechnology is still developing science can be defined as next generation techniques for cancer disease; at the same time it comes with many advantages to treat cancer patients.

  3. Calcium alginate beads with mucoadhesive and ph dependent drug release properties for potential targeting of colon cancerDownload Article

    Priyanka Sinhaa, Ubaidulla Udhumansha, Grace Rathnam, Mani Ganesh, Hyun Tae Jang

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    Capecitabine loaded beads using chitosan succinate (CS)-sodium alginate (SA)-carboxymethyl cellulose (CMC) polymer-blends were developed through ionotropic-gelation technique using CaCl2 as cross-linker. A Box-Behnken design was used to optimize the CS-SA beads by considering the effect of three factors: CS (A;X1), SA (B;X2), and CMC (C;X3), on the response variables Y1 (EE), Y2 (Mucoadhesion), and Y3 (Release). The results of response surface plots allowed an optimized bead to be identified with high drug EE maximum MA and drug release at colon pH. The swelling and mucoadhesivity and suitable sustained drug release pattern over a prolonged period of the beads was found higher at the simulated colonic environment.  The cell proliferation of HT29 cells in the CS-SA-CMC beads decreased significantly compared with that of CP. The Ca2+-crosslinked CS-SA-CMC beads protected in pH 1.2 and prolonged the drug release at pH 7.4, demonstrating that such beads present a promising therapeutic carrier for the colon specific target delivery.

  4. Ultrathin Plus CapsulesTM; A state of the art approach to weight lossDownload Article

    Govind Shukla, Neha S.Giri, D. Sruthi Rao, C.J. Sampath Kumar

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    Obesity is a leading preventable cause of death worldwide, with increasing prevalence in adults and children, and it as one of the most serious public health problems of the 21st century. Obesity increases the likelihood of various diseases, particularly heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Obesity is most commonly caused by a combination of excessive food energy intake, lack of physical activity, and genetic susceptibility. Dieting and physical exercise are the mainstays of treatment for obesity. Diet quality can be improved by reducing the consumption of energy-dense foods such as those high in fat and sugars, and by increasing the intake of dietary fiber. Anti-obesity drugs helps to reduce appetite or inhibit fat absorption together with a suitable diet. Based on these facts an Antiobesity Drug Ultrathin plus capsule has been developed by R&D cell , with Ultrathin Plus capsules A realistic way to Win the war against obesity naturally Present paper reviews the role of ultrathin plus in prevention & control of obesity & obesity related Disorders.