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Abstract
Diabetes Mellitus is associated with damage to the liver, kidney and pancreas of patients. The damage varies in proportion and susceptibility among diabetic patients. This study assessed the hepatoprotective ,nephroprotective and antihyperglycemic activities of ethanolic extract of Scrophularia hypercifolia in alloxan induced diabetic rats. Extraction of the ethanolic extract from aerial parts of Scrophularia hypercifolia was performed by maceration. Thirty rats were divided into five groups. Group I consisted of normal rats that were given only sterile saline solution and served as control group. Group II consists of normal rats that were given alloxan monohydrate (150mg/kg B.W). Group III consists of alloxan induced diabetic rats that were given daily sterile saline solution, drug extract (200mg/kg), Group IV consists of alloxan induced diabetic rats that were given daily sterile saline solution, drug extract (400mg/kg) & Group V consists of alloxan induced diabetic rats that were given daily sterile saline solution and Metformin (14.2 mg/kg body weight) respectively for 21 days by an intragastric tube with free access to food and water. Several biochemical parameters were assessed. Oral administration of the extract resulted in significant reduction in mean values of blood glucose, cholesterol, triglyceride, LDL-C, urea, uric acid, creatinine accompanied by an increase in the mean values of the total protein, albumin, HDL in diabetic rats. The effects produced by this extract were closely similar to a standard antidiabetic drug, metformin. In conclusion, the present study indicates that the ethanolic extract of S. Hypercifolia appears to exhibit nephroprotective, hepatoprotective and antihyperglycemic activities in alloxan induced diabetic rats.Extracts was attributed due to the presence of Flavonoids and Tannins.