Preparation And In Vitro Characterisation Of Indomethacin Sustained Release Tablets

Devendra Patil, Ch. Sunitha, L. Harikiran — Fri, 19 Apr 2024 00:00:00 +0000

The aim of the present study was to develop sustained release formulation of Indomethacin to maintain constant therapeutic levels of the drug for over 24hrs. By using different ratios of synthetic polymers like Methyl cellulose, HPMC K4 M, Hydroxyethyl cellulose (HEC). All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F8) showed better and desired drug release pattern i.e., 99.27% in 24 hours. It contains the Hydroxyethyl cellulose 1:1 ratio as sustained release material. It followed Kors mayer peppas release kinetics mechanism.

Formulation And In Vitro Characterisation Of Milnacipran Hydrochloride Orodispersible Tablets

Ganesh Srinivas, Zareena Shaik, L.Harikiran — Fri, 19 Apr 2024 00:00:00 +0000

Present study is aimed at the development of oral dispersible tablets of Milnacipran Hydrochloride using natural superdisintegrants. Indion 414, Polyplasdone XL 10, Primogel for the preparation of oraldispersible tablets by direct compression method. The blends were evaluated for the pre-compression parameters and all the formulations were found to possess good flow properties. Tablets were compressed by direct compression technique, evaluated for weight variation, hardness, thickness, friability, water absorption, disintegration time, dispersion time drug content and dissolution studies. The drug release profiles of the three superdisintegrants were compared. The optimized formulation F2 was showed good results disintegrated in 3.15 min with 98.89 % drug release.

International Journal of Farmacia

Preparation And In Vitro Characterisation Of Indomethacin Sustained Release Tablets

Formulation And In Vitro Characterisation Of Milnacipran Hydrochloride Orodispersible Tablets