International Journal of Farmacia http://ijfjournal.com/index.php/ijfj en-US drnsriram@gmail.com (Prof.Dr.N.Sriram) drnsriram@gmail.com (Prof.Dr.N.Sriram) Thu, 14 Oct 2021 16:17:22 +0000 OJS 3.2.1.4 http://blogs.law.harvard.edu/tech/rss 60 Formulation of sustained release dosage form of simvastatin and ezetimibe and analytical development by reversed phase high performance liquid chromatography (RP-HPLC) http://ijfjournal.com/index.php/ijfj/article/view/24 <p>The present investigation relates to a process of preparing sustained release dosage forms containing simvastatin and ezetimibe in combination and assay by RP-HPLC method development and validation. Chromatographic separation was achieved on a Water’s Xterra column (250 x 4.6, 5 microns) using a mobile phase consisting of Potassium di hydrogen phosphate and methanol in the rat io of 70:30 at a flow rate of 0.8 ml per minute. The detection was made at 236 nm. The retention time of ezetimibe and simvastatin were 2.6 and 3.4 minutes respectively. The proposed method was validated for Accuracy, Specificity, Precision, linearity, Robustn ess, Limit of Detection (LOD) and Limit of Quantitation (LOQ) were studied as per the ICH guidelines.</p> Ayesha Begum K, Pavani Kasu, Sunitha M Copyright (c) 2021 International Journal of Farmacia http://ijfjournal.com/index.php/ijfj/article/view/24 Mon, 08 Nov 2021 00:00:00 +0000 Phytochemical screening and antiulcer activity of Jasminum mesnyi and Triticum aestivum leaves in albino wistar rats http://ijfjournal.com/index.php/ijfj/article/view/22 <p>The present study was aimed to investigate anti-ulcer activity of ethanolic extract of <em>Jasminum mesnyi </em>and <em>Triticum aestivum </em>leaves using NSAIDs (aspirin) induced ulceration and pylorus ligation ulceration in albino wistar rats. Omeprazole (30 mg/kg body weight) was used as standard antiulcer agent. The ulcer index and percentage protection was estimated individually for both plants in NSAIDs model. Volume of gastric secretion, free acidity, total acidity and pH was estimated in both models using combination 1:1 ratio of extracts of both plants. Ethanolic extract showed significant (p&lt;0.001) ulcer protective action at the doses of 200 and 400 mg/kg body weight individually as well as in combined doses in both animal models. A significant reduction in volume of gastric juice, free acidity and total acidity, along with increase in pH was observed in both models of ulcerations. The antiulcer property of tests extracts was attributed due to the presence of flavonoids and tannins.</p> Mehnoor Farheen, Sobia Farheen Copyright (c) 2021 International Journal of Farmacia http://ijfjournal.com/index.php/ijfj/article/view/22 Mon, 08 Nov 2021 00:00:00 +0000 Phytochemical evaluation and pharmacological screening of Scrophularia hypercifolia for hepatoprotective, nephroprotective and antihyperglycemic activity in alloxan induced diabetic rats http://ijfjournal.com/index.php/ijfj/article/view/25 <p>Diabetes Mellitus is associated with damage to the liver, kidney and pancreas of patients. The damage varies in proportion and susceptibility among diabetic patients. This study assessed the hepatoprotective ,nephroprotective and antihyperglycemic activities of ethanolic extract of <em>Scrophularia hypercifolia </em>in&nbsp; alloxan&nbsp; induced&nbsp; diabetic rats. Extraction of the ethanolic extract from aerial parts of Scrophularia hypercifolia was performed by maceration. Thirty rats were divided into five groups. Group I consisted of normal rats that were given only sterile saline solution and served as control group. Group II consists of normal rats that were given alloxan monohydrate (150mg/kg B.W). Group III consists of alloxan induced diabetic rats that were given daily sterile saline solution, drug extract (200mg/kg), Group IV consists of alloxan induced diabetic rats that were given daily sterile saline solution, drug extract (400mg/kg) &amp; Group V consists of alloxan induced diabetic rats that were given daily sterile saline solution and Metformin (14.2 mg/kg body weight) respectively for 21 days by an intragastric tube with free access to food and water. Several biochemical parameters were assessed. Oral administration of the extract resulted in significant reduction in mean values of blood glucose, cholesterol, triglyceride, LDL-C, urea, uric acid, creatinine accompanied by an increase in the mean values of the total protein, albumin, HDL in diabetic rats. The effects produced by this extract were closely similar to a standard antidiabetic drug, metformin. In conclusion, the present study indicates that the ethanolic extract of <em>S. Hypercifolia </em>appears to exhibit nephroprotective, hepatoprotective and antihyperglycemic activities in alloxan induced diabetic rats.Extracts was attributed due to the presence of Flavonoids and Tannins.</p> Tayyaba Siddiqua Copyright (c) 2021 International Journal of Farmacia http://ijfjournal.com/index.php/ijfj/article/view/25 Mon, 08 Nov 2021 00:00:00 +0000 A comparative study of amlodipine marketed products and their quantitative evaluation by UV – spectrophotometrys http://ijfjournal.com/index.php/ijfj/article/view/23 <p>The present work deals with the comparative study of six different brands of Amlodipine and their Quantitative Evaluation by UV Spectrophotometry. The Evaluation of pharmaceutical equivalency of all the six marketed brands of Amlodipine (5 mg) was done by Quantitative evaluation, Weight variation test, Disintegration test, Friability test and Cost analysis. Objective of the present work is to report the best drug among the six brands also to give a suitable and better method for the comparative study. The Method employs Double Beam UV spectrophotometer [LAB INDIA-UV 3000<sup>+</sup> (version 3.5)]. The selected solvent used was Methanol and the detection was carried out at a wavelength 237 nm. The Calibration graph of Amlodipine and the six brands of Amlodipine were found to be linear with a Regression Coefficient of 0.98 which falls within the limits of Beer-Lamberts law. It was found that Weight Variation Test of Amlodac-5 and Stamlo-5 were not in the acceptance limits and the remaining four tablets passes the Weight Variation test i.e., they lie within the acceptance limits of ( 7.5). The percentage of friability for Amlokind-5 was found to be 0.649% which was less than 0.8%(normal limits) and the remaining brands were found out of limits with little variations. The Disintegration time was found to be 10 seconds (Fastest release) for Amlopres-5 and 4.43 minutes (Slowest release) for Amlodac-5. The tablet Amlokind-5 was found to be best among all the six brands as it is within the acceptable limits. And this method of Quantitative Evaluation was simple, rapid and economical. Hence it can be successfully utilized for comparative studies in routine Lab analysis.</p> Syeda Zaineb kubra Hussaini , Syeda Zaineb Humaira Hussaini Copyright (c) 2021 International Journal of Farmacia http://ijfjournal.com/index.php/ijfj/article/view/23 Mon, 08 Nov 2021 00:00:00 +0000