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A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Elvitegravir in bulk form and Marketed Pharmaceutical dosage form with methanol solvent system. The method is based on the determination of Detection wavelength and plotting a calibration curve. The UV spectrum of Elvitegravir in Methanol Solvent System showed maximum wavelength at 275nm. Beer’s law is valid in the concentration range of 10-60µg/ml. This method was validated for linearity, accuracy, precision, assay, ruggedness and robustness. The method has demonstrated excellent linearity over the range of 10-60µg/ml with the regression equation y=0.0228x+0.0107, and regression coefficient i.e. r2=0.9997 moreover, the method was found to be highly sensitive with LOD (0.2321µg/ml) and LOQ (0.7235µg/ml). Based on the results the proposed method can be successfully applied for the assay of Elvitegravir in various pharmaceutical dosage forms.


Elvitegravir, UV Spectrum, Wavelength, Linearity, Calibration Curve.

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