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Present study is aimed at the development of oral dispersible tablets of Milnacipran Hydrochloride using natural superdisintegrants. Indion 414, Polyplasdone XL 10, Primogel for the preparation of oraldispersible tablets by direct compression method. The blends were evaluated for the pre-compression parameters and all the formulations were found to possess good flow properties. Tablets were compressed by direct compression technique, evaluated for weight variation, hardness, thickness, friability, water absorption, disintegration time, dispersion time drug content and dissolution studies. The drug release profiles of the three superdisintegrants were compared. The optimized formulation F2 was showed good results disintegrated in 3.15 min with 98.89 % drug release.


Oral dispersible tablets Milnacipran Hydrochloride Indion 414 Polyplasdone XL 10 Primogel super disintegranrts direct compression tablets

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