Optimization Of Repaglinide Chronomodulated Delivery System Using Box-Behnken Experimental Design

Abstract

Diabetes mellitus is a disease which shows circadian rhythm in the pattern of peak in the early morning between 4 and 8 a.m. The behaviour, physiology, and biochemistry of organisms changes rhythmically over 24 h. We have prepared chronomodulated release tablet to control plasma sugar level at early morning. Tablet of REP was prepared using CCS and lactose and coated with Eudragit to produce pulsatile release of the drug. Tablet was optimized using Box-Behnken design model. The ideal formulation variables for a formulation were found that 16.14 mg of CCS, 28.91 mg of Lactose, and 4.37 mg of Eudragit and response of tablet was 94.45 % Drug released and 5.99 hrs of lag time (T) with the desirability of around 1. In vitro release data revealed no release was observed in 0.1 N HCl (pH 1.2) and complete release of drug at pH 6.8 conditions.