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The present work deals with the comparative study of six different brands of Amlodipine and their Quantitative Evaluation by UV Spectrophotometry. The Evaluation of pharmaceutical equivalency of all the six marketed brands of Amlodipine (5 mg) was done by Quantitative evaluation, Weight variation test, Disintegration test, Friability test and Cost analysis. Objective of the present work is to report the best drug among the six brands also to give a suitable and better method for the comparative study. The Method employs Double Beam UV spectrophotometer [LAB INDIA-UV 3000+ (version 3.5)]. The selected solvent used was Methanol and the detection was carried out at a wavelength 237 nm. The Calibration graph of Amlodipine and the six brands of Amlodipine were found to be linear with a Regression Coefficient of 0.98 which falls within the limits of Beer-Lamberts law. It was found that Weight Variation Test of Amlodac-5 and Stamlo-5 were not in the acceptance limits and the remaining four tablets passes the Weight Variation test i.e., they lie within the acceptance limits of ( 7.5). The percentage of friability for Amlokind-5 was found to be 0.649% which was less than 0.8%(normal limits) and the remaining brands were found out of limits with little variations. The Disintegration time was found to be 10 seconds (Fastest release) for Amlopres-5 and 4.43 minutes (Slowest release) for Amlodac-5. The tablet Amlokind-5 was found to be best among all the six brands as it is within the acceptable limits. And this method of Quantitative Evaluation was simple, rapid and economical. Hence it can be successfully utilized for comparative studies in routine Lab analysis.


UV Spectrophotometry Quantitative evaluation Amlodipine

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