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Extended-release drug-delivery systems are designed to release drugs over a prolonged period employing steady-rate drug release or controlled release to achieve stable and higher therapeutic potential while minimizing adverse side effects. Sustain release tablets of gemifloxacin were prepared by using polymer Xanthan gum, guar gum, carbopol 937 in all formulation. The ingredients given in table, except glidant and lubricant were thoroughly mixed in mortar and pestle. The wet mass passed through sieve no.16 and c for 30-45. The present work to aim the design, fabrication and evaluation of Gemifloxacin sustained release tablets by wet granulation technique. In this technique Guar Gum and Xanthan Gum were used as polymers for drug released upto extended time period. The Formulations F6 found to satisfy the desired criteria for GFX released from the formulation. The drugs released from the formulations and released mechanism followed for “first order kinetics & Non-Fickian diffusion mechanism” respectively. Finally to achieve a Gemifloxacin sustained released tablets and drugs released up to 12 hrs. The Comparison of the optimized formulation (F6) with market formulation (FM).