Main Article Content
Abstract
The aim of the present study is to Development and evaluate solid dispersion of Naftopidil by using various polymers with different ratios and formulating its tablet. Solid dispersion is an effective way of improving the dissolution rate of poorly watersoluble drugs. Naftopidil were prepared by different methods and evaluated with a view to increase its water solubility and hence to improve the dissolution profile. Solid dispersions were evaluated for solubility and % practical yield. Solid dispersion showing maximum solubility were selected and formulated into tablet. The tablets were exposed to routine qualitycontrolled tests like hardness, friability, weight variation and disintegration. The dissolution profiles of these formulations were studied in 6.8 phosphate buffer and compared to marketed formulation as well as pure drug. At the end of 60min formulation N5 gave the highest drug release that is 99.71% compared to all the formulation. N5 formulation consider as a optimized formulation Naftopidil was significantly improved by preparing solid dispersion.