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Abstract
Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersions based on the concept that the drug is dispersed in an inert water-soluble carrier at solid state. Several water soluble carriers such as Mannitol, PEG 20000 and Urea were used as carriers and Ac Di-Sol used as super disintegrate. Different ratios between drug and carriers were prepared. All formulations were evaluated for pre and post compression studies and those results were found to be within limits. Dissolution studies revealed that formulations SD3 formulation was optimised formulation which contains Drug and Mannitol in the ratio of 1:3. FTIR studies revealed that no interactions between drug and excipients. The present study demonstrated that formulation of Cefixime solid dispersion is a highly effective strategy for enhancing the bioavailability of poorly water soluble drug Cefixime