Effect Of Polymers In The Formulation Of Sustained Release Tablets Of Guaifenesin Using Various Hydrophilic Polymers

Abstract

The aim of the present study was to develop Guaifenesin sustained release tablets to maintain constant therapeutic levels of the drug for over 12 hrs.HPMC K4M, HPMC  K15M, Sodium alginate were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as bulk density, tapped density, cars index, hausners ratio, angle of repose, weight variation, hardness, thickness, friability and drug content. From the dissolution studies it was evident that the formulation F7 showed better and desired drug release pattern i.e., 99.88% in 12hrs.