Main Article Content
Abstract
This study focuses on the development and assessment of immediate-release tablets with Empagliflozin and Lingagliptin for effective type 2 diabetes mellitus management. Using the wet granulation technique, tablets were made with Excipients like mannitol, microcrystalline cellulose, Crospovidone, and Crospovidone. The compatibility of drugs and Excipients was confirmed through FTIR analysis. The parameters for pre-compression and post-compression fell within acceptable limits, guaranteeing good flow properties and mechanical strength. Batch F6 demonstrated optimal results among all formulations, exhibiting acceptable hardness, friability of less than 1%, and uniform weight and drug content. Rapid drug release was demonstrated in in-vitro dissolution studies, with 98.96% of Empagliflozin and 99.32% of Linagliptin achieved within 30 minutes, adhering to first-order kinetics. Stability studies, carried out according to ICH guidelines, showed no significant changes in physical or chemical properties. The optimized formulation was shown to be stable and effective, making it appropriate for producing an immediate therapeutic response in diabetes management.