Formulation And In Vitro Evaluation Of Ambroxol Hcl Fast Dissolving Films Using Various Polymers

Abstract

Ambroxol HCl is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. Ambroxol is often administered as an active ingredient in cough syrup. Present work aimed at preparing quick onset of action which is beneficial in respiratory diseases, aiding in the enhancement of bioavailabity and is very convenient for administration without the problem of swallowing and using water.  The film was prepared by using polymers such asHPMC,HPMC K100 and HPMC K1500by a solvent casting method.  They wereevaluated for physical characteristics such as Thickness, Weight Variation, Disintegration time, Drug content, Tensile strength, % Elongation, Folding Endurance and Invitro Dissolution Studies give satisfactory results. The in vitro dissolution time of the optimized batch F4 was found to be 98.97 %.  The optimized batchin vitro disintegration time was found to 14 to 22 sec.