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Abstract
To develop and evaluate Nevirapine (NVP) Extended release tablets for reducing the dosing frequency using Hypermellose USP and lactose monohydrates USP used as rate retarding polymers and extragrnaular ingredient Magnesium stearate as lubricant.
Methods: Tablets were equipped by using roller compaction technique by using Quality by Design (QbD) and Design of Experimentation (DoE) to study the effect of various process related parameters like Bulk density, Tapped density, Compressibility index, mesh size and in-vitro release data at 16 the hour.
Results: Obtained results had recommended that focus of polymer had shown a potential consequence over many process parameters and in-vitro drug release studies recommended that formulated tablets had presented a sustained release up to 16h when compared with marketed formulations.
Conclusion: From the obtained results it can be concluded that formulation of Nevirapine ER Tablets employing QbD lead to a single dose per day in the management of HIV/AIDS.