Main Article Content
Abstract
Curcumin a natural polyphenol with strong anti-inflammatory, antioxidant, and anticancer properties, but face challenges in clinical application due to its low bioavailability, rapid metabolism, poor water solubility. To address these issues, Curcumin loaded microneedle (MN) patches have emerged as an innovative transdermal drug delivery platform. These patches create microchannels in the skin, enabling efficient delivery of curcumin while bypassing gastrointestinal degradation and first-pass metabolism. Additionally, microneedles offer a painless and patient- friendly alternative to oral and injected route, with the potential for sustained and controlled drug release. Recent advancement in studies indicate that these systems can enhances therapeutic outcomes in various condition including chronic inflammation, wound healing and cancer therapy. This review article highlights the curcumin detailing its pharmacological properties, limitation and challenges. Additionally, it focuses on microneedle technology including material employed in their fabrication and different types of microneedle available. The article also discusses recent advance and therapeutic use of curcumin loaded microneedle patch for transdermal drug delivery, which can be used to treat various medical conditions.