Siddha medicine is a traditional healing system that has its roots in southern India and is considered one of the oldest medical practices in the country. However, the Indian Medical Association has labeled degrees in Siddha medicine as "fraudulent" and views its therapies as pseudoscientific, suggesting that they pose a risk to public health due to a lack of scientific training. Boerhavia diffusa (BD) Linn. (Nyctaginaceae) is a prominent medicinal plant recognized in traditional Indian medicine and in various regions worldwide, including South America and Africa. Its different parts, particularly the roots, are utilized for treating gastrointestinal issues, liver protection, and gynecological conditions in these areas and across India. Ayurvedic literature lists over 35 formulations that feature BD as a key ingredient. In Ayurveda, BD is categorized as a "rasayana" herb, known for its anti-aging properties, ability to restore youth, enhance vitality and cognitive function, and prevent diseases. These attributes suggest that it boosts the body's resilience against various challenges, thereby offering hepatoprotective and immunomodulatory benefits. The administration of Boerhavia diffusa extract has been shown to enhance liver conditions in Wistar albino rats. The positive effects of this extract are evident in both the histopathological characteristics and the hepatic serum markers of the rats. Histopathologically, the severity of hepatosteatosis was reduced in the groups receiving Boerhavia diffusa extract, with a clear dose-dependent response observed. Initial qualitative assessment of phytochemicals aimed at detecting the presence of compounds such as phenols, flavonoids, and tannins.