Main Article Content
Abstract
Orally dispersible tablets (ODTs) quickly break down or dissolve in the mouth without the need for water. The demand for orally disintegrating tablets (ODTs) has experienced a significant surge, leading to a substantial expansion of this field within the pharmaceutical business and academics. Orally dissolving tablets are becoming increasingly popular compared to regular tablets since they are convenient to administer and suitable for patients. This study aims to create orally dispersible tablets of Gatifloxacin (GTF) utilizing natural superdisintegrants. The preparations were made by the direct compression approach. The optimal flow properties, such as angle of repose, bulk density, and tapped density, were demonstrated by the amalgamation of all the formulations. The produced tablets exhibited favorable post-compression characteristics and successfully met all quality control evaluation criteria according to the I.P limits. The F1 formulation exhibited the highest drug release, specifically 98.75%, within a 20-minute timeframe. Therefore, it is regarded as the optimum formulation. Out of all the formulations, the F1 that uses plantago ovata as a superdisintegrant satisfies all the requirements. In comparison to other formulations, it has demonstrated exceptional in vitro disintegration and dissolution. The study came to the conclusion that GTF may be successfully made into dispersible tablets since it meets all the requirements for a dispersible tablet and can serve as a substitute for the traditional tablets that are currently on the market.