Main Article Content
Abstract
The medication's efficacy and safety profile may be enhanced, dosage may be decreased, and the onset of action may be accelerated with oral disintegrating films. Compared to other conventional dose forms, it dissolves more quickly, is more stable, and has a longer half-life. Doxazosin mesylate (DXZ) was selected for the sublingual route in order to produce fast-dissolving films that dissolves in saliva quickly and without the need for water. The influence on the dissolution profile is measured using DXZ. The solvent casting method was used to create the oral disintegrating films (ODF), which contained PEG 400 as plasticiser along with water-soluble polymers such as HPMC E5, HPMC E15, and locust bean gum in different quantities. The results showed that the medicine vanished quickly. Data showed the DM9 dissolved quickly, releases 99.96 drug in 20 min. This study advises giving DXZ orally with a film that dissolves when ingested. DM3 (HPMC E5) disintegrates in 19 seconds, and DM6 (HPMC E15) in 21 seconds. As compare to synthetic polymer, natural polymer locust bean gum disintegrates within 9 seconds only. No particles were discovered after disintegration. Based on disintegration time and dissolving trials, it was concluded that DM9 was the best formulation.