Main Article Content
Abstract
The medication's efficacy and safety profile may be enhanced, dosage may be decreased, and the onset of action may be accelerated with oral disintegrating films. Compared to other conventional dose forms, it dissolves more quickly, is more stable, and has a longer half-life. Valsartan (VST) was selected for the sublingual route in order to produce fast-dissolving films that dissolves in saliva quickly and without the need for water. The influence on the dissolution profile is measured using VST. The solvent casting method was used to create the oral disintegrating films (ODF), which contained PEG 400 as plasticiser along with a natural polymer locust been gum; SSG and CCS used as a superdisintegrants in different concentrations.The results showed that the medicine vanished quickly. Data showed the VF3 and VF7 dissolved quickly, releases drug in 20 min. VF3 disintegrates in 46 seconds, and VF7 in 62 seconds. No particles were discovered after disintegration. Based on disintegration time and dissolving trials, it was concluded that VF3 and VF7 were the best formulation.