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Abstract
A simple, accurate, precise approach was devised to estimate Indomethacin (IDM) and Sulphamethaxazole (SMZ) in tablets. A Phenomenex Luna C18 250 x 4.6 mm, 5mm chromatogram was conducted. Mobile phase with Buffer 10Mm Ammonium Acetate: Acetonitrile 50:50v/v was injected through column at 0.7ml/min. Optimal wavelength was 285nm. IDM and SMZ retention times were 2.861min and 7.273, respectively, and their %RSDs were 0.9 and 0.9. % Recovery was 100.46% for IDM and 100.20% for SMZ. IDM and SMZ regression equations yielded LOD, LOQ values of 0.08, 0.25, and 0.04, 0.12. IDM regression equation is y = 15895x + 41.3 and SMZ y = 3720x + 244.1. The method devised was straightforward and economical for routine quality control tests in industries because retention and run times were reduced.