Main Article Content
Aim: The aim of the present study was an attempt to prepare and evaluate Curcumin phytosomes by using Soya lecithin as a polymer for treating the Cancer potentially.
Methodology: The formulation FA1 to FA5 were prepared by Reflux method and the formulation FB1 to FB5 were prepared by Rotary evaporation methods, by varying the concentration of polymer, which were significantly affect the in vitro drug release. The in vitro drug release studies were carried out by using phosphate buffer pH 6.8.
Results: Drug and physical mixture were characterized by FTIR, the result of FTIR study showed that no interaction between drug and polymer. The in vitro drug release and release kinetics of formulations showed controlled release. The other formulation parameters of formulated Phytosomes were evaluated which showed better results.
Conclusion: It was concluded that the formed Phytosomes showed prolonged drug release. Curcumin Phytosomes promote a fast and effective action against the Cancer. From the in vitro drug release and release kinetics studies it can be concluded that the formulation FB5 prepared by Rotary evaporation method has better potential of control drug release than Reflux method.