Comprehensive Review on Effervescent Granules Formulation

Abstract

The present work is based on the formulation of effervescent granules of  Tinidazole and Ofloxacin and their comparative study. Seven such formulations were prepared using cetyl alcohol and tartaric acid and sodium bicarbonate as effervescent base at different ratios. The granules were prepared by the melt granulation method, and they were evaluated for flow property (such as angle of repose, bulk density, tapped density, and Carr’s index), particle size, pH, effervescence time, in vitro dissolution studies, and drug content. Effervescence is defined as the evolution of bubbles of gas from a liquid as a result of a chemical reaction. Effervescent mixtures have been known and used medicinally for many years. Effervescent powders used as saline cathartics were available in the eighteenth century and were subsequently listed in the official compendia as compound effervescent powders. These were more commonly known as ‘Seidlitz powders’.