Main Article Content
Abstract
Formulation and evaluation of floating tablets of Ofloxacin. In the present study the formulations were prepared by direct compression method using different proportions of HPMC K4M, HPMC K15M, and HPMC K100M as Swellable polymers. Sodium bicarbonate is used as buoyancy-imparting agent. The prepared formulations were evaluated for different parameters during its Pre-compression and Post-compression stages. The release characteristics of the formulations were studied in in-vitro conditions. The in-vitro dissolution study of formulation F8 was 99.34 % within 12 h for good release and was fitted to kinetics of drug release for R2 value of Higuchi release mechanism model is 0.964. As an extension of this work for formulation F8, bioavailability, pharmacokinetic, and in-vivo studies can be done in future to develop as suitable candidate for a novel drug delivery system.