Formulation and evaluation of floating controlled release tablets of imatinib mesylate using hydrophilic matrix system

Abstract

The present investigation concerns the development of floating drug delivery system of Imatinib Mesylate which is to increase the gastric residence time thus prolonging the drug release with localized drug action .Floating tablets were prepared with direct compression method by using different polymers with ratios. The prepared Floating Tablets were evaluated for various parameters like Hardness, Thickness, Friability, Uniformity of drug content, Invitro floating studies and In vitro drug release. All the Floating tablets were showed good results. Amongall IM4 formulation showed good drug release of 99.87% for 12hrs.