Main Article Content
Abstract
The purpose of this work was to develop gastroretentive floating tablets of Metronidazole. Floating tablets were prepared by direct compression method using gas generating agents such as sodium bicarbonate and citric acid and polymers like HPMC K 100,Eudragit and Ethyl Cellulose. Formulations tried for different ratios of drug and polymers to get desired release profile. Prepared tablets M1- M9 were evaluated in term of precompression and post compression parameters. Metronidazole floating tablets were prepared direct compression method were found to be good with out chipping , capping and sticking. The drug content was uniform in all the tablet formulation indicating uniform distribution of drug within the matrices. All prepared tablets showed satisfactory floating lag time and total floating time found to be 12hrs. Among all formulations M5 showed the drug release most sustained manner and showed 99.56 % of in vitro drug release at end of 12hrs and selected as the best formulation. The release Kinetics was done for optimized formulation.