Main Article Content
Abstract
The main objective of present work was to formulate and evaluate sustained release matrix tablet of Timolol Maleate using different polymers like Fenugreek, Tamarind gum and Grewia Gum. Formulation of matrix tablets was prepared by using powder blend of different ratios of polymer to get desirable drug release profile. Direct compression method was used to formulate tablets. The evaluation of physical properties of tablet were done the in vitro drug release study was performed in 0.1N HCL for 2hours and in phosphate buffer PH 6.8 up to 10 hours. Evaluation parameters of formulated matrix tablets were hardness, friability, thickness, drug content, weight variation and the in vitro drug release rate pattern results indicated that the formulation F5 was the most promising formulation as the drug release from this formulation was high compared to other formulations. In formulation F5 percentage drug release of Timolol Maleate sustained release was 99.64 % 12hrs.