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Abstract
The growing emphasis on environmental protection and sustainable industrial practices has significantly transformed pharmaceutical research and quality control, leading to the development of Green Analytical Chemistry (GAC). Traditional analytical methods employed in pharmaceutical laboratories often rely heavily on toxic organic solvents, energy-intensive instrumentation, and extensive sample preparation procedures, resulting in substantial chemical waste and environmental burden. Green analytical techniques aim to address these concerns by minimizing hazardous reagent consumption, reducing waste generation, lowering energy requirements, and improving operator safety while maintaining analytical accuracy and reliability. Recent innovations, including ultra-high-performance liquid chromatography, supercritical fluid chromatography, capillary electrophoresis, microextraction methods, microfluidic devices, and ambient spectroscopic techniques, have emerged as promising alternatives to conventional analytical platforms. The integration of artificial intelligence, automation, and digital analytical workflows further enhances sustainability by optimizing experimental conditions and reducing unnecessary resource utilization. In addition, several green assessment tools, such as the Analytical Eco-Scale, Green Analytical Procedure Index (GAPI), AGREE metric, and ComplexGAPI, have been developed to quantitatively evaluate the environmental performance of analytical procedures. These advancements support the pharmaceutical industry's transition toward environmentally responsible manufacturing and quality assurance practices. Despite challenges related to regulatory acceptance, method validation, and implementation costs, green analytical chemistry continues to evolve rapidly, driven by global sustainability initiatives and stricter environmental regulations. This review discusses the fundamental principles, recent technological developments, pharmaceutical applications, current limitations, and future prospects of green and sustainable analytical techniques, highlighting their growing importance in eco-friendly drug analysis and sustainable healthcare systems.