Phytochemical screening and antiulcer activity of Jasminum mesnyi and Triticum aestivum leaves in albino wistar rats
Keywords:
Jasminum mesnyi, Triticum aestivum, Aspirin, Pylorus ligation, GastroprotectiveAbstract
The present study was aimed to investigate anti-ulcer activity of ethanolic extract of Jasminum mesnyi and Triticum aestivum leaves using NSAIDs (aspirin) induced ulceration and pylorus ligation ulceration in albino wistar rats. Omeprazole (30 mg/kg body weight) was used as standard antiulcer agent. The ulcer index and percentage protection was estimated individually for both plants in NSAIDs model. Volume of gastric secretion, free acidity, total acidity and pH was estimated in both models using combination 1:1 ratio of extracts of both plants. Ethanolic extract showed significant (p<0.001) ulcer protective action at the doses of 200 and 400 mg/kg body weight individually as well as in combined doses in both animal models. A significant reduction in volume of gastric juice, free acidity and total acidity, along with increase in pH was observed in both models of ulcerations. The antiulcer property of tests extracts was attributed due to the presence of flavonoids and tannins.
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