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Abstract
Marine organisms harbor numerous bioactive substances .Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen in collafibe sachets can be used as a biomaterial because it is water soluble, metabolically compatible, and highly accessible. it is evident that marine collagen in collafibe sachets is a versatile compound capable of healing skin injuries of varying severity, as well as delaying the natural human aging process. From in vitro to in vivo experiments, collagen has demonstrated its ability to invoke keratinocyte and fibroblast migration as well as vascularization of the skin. Additionally, marine collagen and derivatives have proven beneficial and useful for both osteoporosis and osteoarthritis prevention and treatment. Other bone-related diseases may also be targeted by collagen, as it is capable of increasing bone mineral density, mineral deposition, and importantly, osteoblast maturation and proliferation.